Hawking appeared at a talk at the Sydney Opera House on Saturday in the form of a 3D hologram. His image was beamed in from Cambridge University, UK to Sydney Australia.
The professor discussed a range of topics, from his diagnosis with motor neurone disease to the universe’s mysteries and the future of Earth.
However things took a different turn when somebody from the audience decided to spice things up by asking for Hawking’s opinion about Zayn leaving One Direction
“What do you think is the cosmological effect of Zayn leaving One Direction and consequently breaking the hearts of millions of teenage girls across the world?”
Stephen Hawking, having a sense of humor, did not shoot down the question but instead became the new hero of One Direction fans.
“Finally, a question about something important,” he replied.
“My advice to any heartbroken young girl is to pay close attention to the study of theoretical physics, because one day there may well be proof of multiple universes.”
“It would not be beyond the realms of possibility that somewhere outside of our own universe lies another different universe – and in that universe, Zayn is still in One Direction.”
He also addressed the girl who asked the question "The girl may like to know that in another possible universe, she and Zayn are happily married."
Mr Hawking, 73, ended his speech by inspiring people to “look at up at the stars and not down at your feet.”
He added “Try to make sense of what you see and wonder about what makes a universe exist,” he said.
“Be curious, and however difficult life may seem, there is always something you can do and succeed at. It matters that you don’t just give up.”
Finally, he quoted Star Trek’s Captain Kirk. “Beam me up Scotty!” he said, before his digital image disappeared in a flash of light.