Some 42 people died and another 8 were injured, the officials said on Friday, after a bus and a truck crashed and quickly caught fire in a collision in Southern France.
The cause of the accident is not yet clear. It happened only minutes after the bus had set off from a nearby town in the east of Bordeaux.
The French media reported the incident occurred at around 07:30 local time (05:30 GMT) on a single carriageway road just outside the village of Puisseguin.
French President Francois Hollande tweeted about the crash that the government "is fully mobilised on this terrible tragedy."
Un accident a provoqué de nombreux morts en Gironde. Le gouvernement français est totalement mobilisé sur cette terrible tragédie.
— François Hollande (@fhollande) 23 Ekim 2015
A fire official told reporters that pensioners from an elderly people's association on a day trip in the nearby town of Petit-Palais-et-Cornemps died in the blaze.
The casualty claimed at least 41 passengers on the bus and the truck driver while only eight passengers were able to survive the crash.
In 1982, 52 people had died in an accident in Beaune, France.
Friday’s accident is reportedly the worst French road disaster since then.