38-year-old giant panda Jia Jia had to be put down after her health rapidly deteriorated over the last two weeks.
The world's oldest ever giant panda in captivity died on Sunday, aged 38 at a Hong Kong theme park, officials said.
Jia Jia was put down after her health rapidly deteriorated over the last two weeks leaving her unable to walk without difficulty, a statement from the Ocean Park Hong Kong theme park said.
"Her state became so debilitated that based on ethical reasons and in order to prevent suffering, veterinarians from the Agriculture, Fisheries and Conservation Department and Ocean Park agreed to a humane euthanasia for Jia Jia," the theme park said.
"This is a day we knew would eventually come, but it is nevertheless a sad day for everyone at the Park, especially for the Park's keepers who took care of her over the years," Ocean Park chairman Leo Kung added.
Born in the wild in China's Sichuan province in 1978, Jia Jia was given to Hong Kong in 1999 to mark the semi-autonomous city's handover by Britain two years earlier.
Her health declined over recent days, her food consumption slumped from more than 10 kgs a day to less than three and her weight also declined.
"Those who teach us the most about humanity - aren't always humans" - Donald L. Hicks— WWF_Australia (@WWF_Australia) October 17, 2016
RIP Jia Jia 1978 - 2016 https://t.co/5si4Z6wijw
There are fewer than 2,000 pandas now left in the wild, according to the World Wildlife Fund, as their habitats have been ravaged by development.
Given their low birthrate, captive breeding programmes have become key to ensuring their survival.
According to Ocean Park, Jia Jia gave birth five times to six panda cubs.