Two people were killed and 12 others were wounded on Monday in an explosion which hit a Shiite mosque in the Saudi city of Najran.
Saudi's al Ikhbariya channel said that the suspected bomber was injured during the explosion.
ISIS took responsibility for the attack at the Shiite mosque.
A group post on Twitter stated that the attack was aimed at "the rejectionist Ismailis" referring to the Ismaili Shiite sect who accounts minority in Saudi Arabia.
Interior Ministry spokesman Maj. Gen. Mansour al Turki affirmed the explosion and stated that the attack occurred as worshipers were leaving the mosque after sunset prayer. Injured victims are being treated in hospitals close to the region.
Turki also said that authorities have launched a probe into the attack.
ISIS attacked Shiite community at the mosque in May killing 21 people and injured over 50 in Saudi Arabia's Eastern Province of Qatif.
A suicide bomber identified as Abu Amer al Najdi, detonated explosives wrapped around his body in the middle of the Ali Ibn Abi Taleb Mosque in Qadih village of Qatif province.
Qatif is home to the Saudi Shiite minority and the place of past demonstrations, demanding rights for Shiites in the country.
Shiites constitute an estimated 10 to 15 percent of Saudi Arabia’s population and are mostly concentrated in the Qatif and al Ahsa provinces.
The attacks may further increase tensions between the country’s Shiite community and Saudis who adhere to the Wahhabi School of Sunni Islam.