An explosive laden vehicle parked outside an arms depot belonging to Iranian backed Houthi rebels has exploded in the coastal city of Shukra in southern Yemen.
A local official told the AFP news agency that 12 Houthis were killed in the explosion and eight others were wounded.
No group took immediate responsibility for the attack.
Backed by Iran, the Houthis took control of the Yemeni capital of Sanaa in September through an armed uprising, causing the Yemeni government to flee to Aden after the group attempted to disband it in January.
Houthi forces began a military campaign to take Aden in April, forcing the government to escape Yemen to neighbouring ally Saudi Arabia, where it has set up its office in the country’s capital Riyadh.
Pro-government forces continue to clash with Houthi forces across the country as an Arab coalition led by Saudi Arabia launches air strikes to prevent further gains by the Houthi militia.