The Syrian Arab Red Crescent said on Monday that a total of 51 trucks of relief materials have entered Al Moaddamyeh, a town to the southwest of Syrian capital Damascus.
Civilians in five besieged areas in Syria will benefit from the much needed aid, which include blankets, soaps, diapers and other daily necessities.
Officials from the Syrian Arab Red Crescent noted that food is not included in the packages.
The UN Resident and Humanitarian Coordinator in Syria Yacoub El Hillo, said on Sunday evening that the United Nations plans multiple aid operations from Monday to Friday and will expand the humanitarian aid coverage to 150,000 besieged Syrians
He also said the UN hopes to expand the coverage of humanitarian aid to 1.7 million Syrians before the end of March.
Efforts to relieve civilians under siege were forced to increase after the UN's human rights chief said thousands could die of hunger.
"The deliberate starvation of people is unequivocally forbidden as a weapon of warfare. By extension, so are sieges," Zeid Ra'ad Al Hussein said, warning that "thousands of people risk starving to death.''