Thirteen year-old Palestinian, Ahmad Sharaka, was shot dead by Israeli security officials on Sunday during clashes at a checkpoint south of al Bireh in Ramallah district, medics said.
Palestinians were demonstrating outside Beit El, a Jewish-only settlement near Ramallah, when Israeli forces opened fire on the demonstrators.
Sharaka was shot in the neck with a live round, medics reported, he was then rushed to the Palestinian Medical Complex in Ramallah where doctors operated on him, before he surrendered to his wounds.
He is considered to be the third 13-year-old to be shot dead by Israeli forces since the beginning of October.
"The boy [Sharaka] had a wound from a live bullet in the neck when he arrived at the emergency room," an official at the hospital told Al Jazeera.
"Unfortunately his wounds were so severe that he could not make it and he died despite all of the medical procedures,” he added.
"We received four more patients suffering from live ammunition injuries in lower extremities."
Another wounded Palestinian brought into the hospital suffered from a shot in the leg with a live round while another was injured by a rubber-coated steel bullet.
Two others reportedly suffered excessive tear gas inhalation during the protest.
Israeli authorities reportedly removed large objects in the area using bulldozers, in an attempt to prevent Palestinian protesters from finding protection.
Frustration has increased as Israel continues to construct Jewish-only settlements throughout the West Bank in defiance of international law.
Adding to that, tensions over the al Aqsa Mosque compound has also sparked weeks of protests across the occupied Palestinian territory.
At least 55 Palestinians have been shot and injured with live fire, and 77 injured by rubber-coated steel bullets, as reported by the Palestinian Red Crescent on Sunday.
The Palestinian Authority Ministry of Health stated on the same day that Israeli forces have shot more than 1,300 Palestinians with live and rubber-coated bullets since the beginning of this month.
'Green light to shoot children'
"If you follow the rhetoric of Israeli leaders, if you listen to their statements, it is clear that soldiers and settlers have been given the green light to shoot Palestinian children," Ayed Abu Qtaish, accountability director of Defence for Children International - Palestine, told Al Jazeera.
Earlier on Sunday, Israeli air strikes hit a home in the Gaza Strip, killing a mother and her child. The victims were a 27-year-old pregnant woman, Noor Hassan, and her three-year-old daughter Rahaf.
On Saturday, Israeli soldiers shot dead two Palestinian children aged 13 and 15, Marwan Barbakh and Omar Othman, respectively, in the strip.
A day earlier, 15-year-old Muhammad al-Raqb was also shot dead during similar protests. He was among the six Palestinians who died due to Israeli bullets in protests across Gaza.
"As always, we do not expect the soldiers who shot and killed children to be held accountable," said Qtaish.
Since the beginning of the year, nine Palestinians under the age of 18 have been killed by Israeli soldiers or settlers, he added.