Palestinian demonstrators clashed with the Israeli peolice on the fifth day of unrest, after Israeli police raided Al Aqsa Mosque compound last Sunday.
Israeli sources claim they were trying to stop Palestinian attempts to disrupt visits by Jews and foreign tourists on the eve of the Jewish New Year.
Friday's clashes followed days of unrest at Jerusalem's Al Aqsa Mosque compound, where Muslim men under the age of 40 have been banned from attending prayers.
Israeli police said that the Palestinians attacked them with firebombs and wounded four Israeli police officers in occupied East Jerusalem while they were trying to re-open a road that the protesters were blocking.
The new wave of clashes started on September 13, after Israeli police stormed the Al Aqsa Mosque compound to detain what they called Palestinian "stone throwers."
Jerusalem Mayor Nir Barkat told the Jerusalem Post on Friday that the Palestinians "will pay a dear price" for their actions."
"The message I have to those causing the disorder is that they are endangering their own lives," he added.
"We will prosecute them, and they will pay dearly."