Two Palestinians were shot dead by Israeli police after they allegedly fired on a bus in the Old City of Jerusalem on Wednesday, leaving one person seriously wounded, Israeli police said.
The shootings were the latest in a string of attacks coinciding with US Vice President Joe Biden's arrival on Tuesday.
The first shooting occurred in an ultra-Orthodox Jewish neighbourhood of northern Jerusalem, police said. A driver returned fire at the two men before they fled.
On Tuesday, a Palestinian went on a stabbing spree along the Tel Aviv waterfront, killing an American tourist and wounding 12 people.
Around a 15-minute walk from where the stabbings took place, Biden met Israel's former president Shimon Peres.
Three other incidents occurred on Tuesday, including two in Jerusalem and one in Petah Tikva near Tel Aviv.
Violence in Israel and the Palestinian territories since last October has killed at least 190 Palestinians and 28 Israelis. Palestinians were killed either during alleged stabbing or car-ramming attacks, or during clashes and demonstrations.