Israeli soldiers in the Gaza Strip shot dead two Palestinian children aged 13 and 15 during confrontations on Saturday.
Israeli security forces also killed two Palestinian youths at an East Jerusalem Refugee Camp earlier in the day, one of whom reportedly injured two ultra-Orthodox Jewish men in a knife attack, an Israeli spokesman said.
The latest incident comes as violence rages in the occupied West Bank and East Jerusalem, less than a day after six people were killed during a protest along the Israeli border.
The Palestinian Health Ministry revealed the names of the slain children to be Marwan Barbakh and Omar Othman and said they were killed with live ammunition in Khan Younis.
Among the six others killed during protests in al-Faraheen village on Friday was another 15-old child.
Israeli-occupied eastern Jerusalem has witnessed an increase in violence in the past three weeks. Palestinian President Mahmoud Abbas has warned that the unrest could trigger a “third intifada” and the situation has been steadily escalating since October 3.
On Friday, six Palestinians are reported to have been killed, while more than 20 were wounded in violent clashes between Palestinian youth and Israeli forces east of Gaza City and Khan Yunis along the border with Israel.
Witnesses reported that Israeli snipers fired at the Palestinians from along the border fence, 400 metres away from where they were protesting. Demonstrations were called to march in solidarity with Palestinians in the occupied West Bank and Jerusalem.
Palestinian Liberation Organisation Secretary General Saeb Erakat accused Israeli Prime Minister Benjamin Netanyahu and his government of "committing a new massacre of Palestinians" in Gaza.