Yahya Hamid, a senior Muslim Brotherhood leader who currently resides in Turkey, said the trial had "fallen below all international standards" in a news conference in Istanbul.
"This verdict is a nail in the coffin of democracy in Egypt," said Hamid, a former minister in Morsi's government and head of international relations for the Brotherhood.
The prosecuted called for a "popular uprising" next Friday as a response to the politically biased sentences.
An Egyptian court had upheld a death sentence against deposed president Mohamed Morsi and the MB grand leader in Mohamed Badie in the jail break during the 2011 uprising that forced deposed autocrat Hosni Mubarak from office.
The Muslim Brotherhood also called the verdicts “null and void.”
"The Brotherhood calls on the honorable among this nation to participate in a popular uprising next Friday against the death sentences, detentions, kidnappings, and forced disappearances," the group said on their verified facebook page.
The court sentenced prominent Muslim Brotherhood leaders Khairat el Shater, Mohamed el Beltagy and Ahmed Abdelaty to death in the espionage case.
Senior Muslim cleric, Youssef Qaradawy was sentenced to death in absentia as well in the jailbreak case, Qaradawy is over 80 years old and resides in Qatar.
Egyptian Judiciary accused the defendants of sending MB member to Gaza through tunnels, to receive military training by the Iranian revolutionary Guard and the Lebanese Shiite group Hezbollah, to ultimately return home and execute what the group described as “terrorism acts and disrupting peaceful citizens’ lives.”
All verdicts are vulnerable to court appeal, which can ultimately lead to reduced sentencing. The court-appointed lawyer for Morsi told Reuters on Tuesday he would appeal against the death sentence as soon as possible.
Tuesday's ruling comes after the court consulted Egypt's grand mufti, the country’s most senior religious authority. Morsi along with over 100 other defendants were sentenced to death in May, and so the advisory opinion of the Mufti was in order.
Earlier on Tuesday, the same court sentenced Morsi along with 15 others to life in prison in a separate case related to spying for Palestinian group Hamas, Lebanese group Hezbollah, and Iran.
A life in prison in Egypt stipulates 25 years in prison.
The mass death sentences had drawn criticism from the United States, the European Union, Turkey and Amnesty International.
Despite US concerns, Cairo remains one of Washington's closest security allies in the region. In late March, US President Barack Obama lifted a hold on a supply of arms to Cairo, authorising deliveries of US weapons valued at over $1.3 billion.
Turkish Foreign Minister Mevlut Cavusoglu said on Tuesday "There is no law, there is no justice," during a news conference broadcast live by TRT state television.
"We weren't actually surprised... to see such a political verdict from a regime like that," he added.
The group maintains it is committed to peaceful activism. The defendants chanted "Down, down with military rule," as they were led into the court.