The al-Qaeda-affiliated Nusra Front in Syria claimed responsibility for a suicide bombing on Monday in Rukn al-Din in the central of the Syrian capital Damascus through a post on its official Twitter account.
The bombing targeted a senior army officer, Mohammed Eid, who was wounded according to monitoring group while the Syrian military denied.
The blast was executed by three Nusra fighters, two of them were killed by Syrian regime forces while the third blew himself up.
The last suicide bombing in Damascus took place two years ago, before regime forces pushed back opposition fighters to the outskirts of the city.
"A major general who heads the munitions and supply division of the Syrian army was injured and one of his companions killed and two hurt in the rebel attack," Head of Syrian Observatory for Human rights (SOHR), Rami Abdulrahman said.
Many senior officials live in Rukn al-Din and major branches of Syria's intelligence apparatus are based there as well, according to the Observatory.
Eyewitnesses said Syrian security forces had arrested many people after the explosion.
Syrian opposition forces alongside with the Nusra Front have conducted a series of assassinations recent days, targeting officers of Syrian President Bashar al Assad's regime.
Another officer, Amin Qasim, was killed in his home on Monday morning.
Last week, two more high-rated officers were killed in Aleppo and Homs.
SOHR also reported that the regime conducted air strikes on Sunday in Aleppo, targeting a school and a kindergarten killing seven civilians including four children, as opposition fighters advance towards the centre of the city.
Less than 800 metres now separate rebel fighters from the city’s Saadallah al-Jabri Square, a regime stronghold.
According to activists, chlorine gas was used for the eighth time in air strikes in the Idlib province on Monday causing more than 20 people to suffer from suffocation.
Life in Syria is “ increasingly unbearable for civilians" due to aerial bombardment" Philip Luther, Director of Amnesty International’s Middle East and North Africa Programme said.
According to U.N. estimates, the four-year-long Syrian Civil War has claimed the lives of more than 220,000 people.