Israeli police shot dead one Palestinian on Sunday after two men allegedly opened fire on people at the central bus station in the southern Israeli city of Beersheba.
Medical officials said six people were taken to hospital, two of them in serious condition, two moderate and two lightly injured.
An Israeli police spokesman confirmed that the Palestinian man was killed and the other suspected man was also injured by Israeli forces.
There was no immediate information about the identity of the second man.
One of the suspects was allegedly armed with a rifle and the other had a pistol, police claimed.
Since October 1, at least 44 Palestinians - including alleged attackers, unarmed protesters and bystanders - have been killed either by Israeli authorities or settlers.
Seven Israelis have also been killed in attacks this month.