The legendary actor died at his home from complications related to Alzheimer's disease that he had chosen to keep a secret from his fans.
Gene Wilder, whose kinky curls and startling blue eyes brought a frantic air to roles in the movies Willy Wonka and the Chocolate Factory, Young Frankenstein and Blazing Saddles, died on Monday at the age of 83, his family said.
Wilder, whose best work came in collaborations with director-writer Mel Brooks and actor Richard Pryor, died at his home in Stamford, Connecticut, from complications of Alzheimer's disease, the family said in a statement.
Gene Wilder-One of the truly great talents of our time. He blessed every film we did with his magic & he blessed me with his friendship.— Mel Brooks (@MelBrooks) August 29, 2016
Wilder's nephew, Jordan Walker-Pearlman, said the actor had chosen to keep his illness secret so that children who knew him as Willy Wonka would not equate the whimsical character with an adult disease.
Wilder's barely contained hysteria made him a go-to lead for director-writer Mel Brooks, who cast him in Blazing Saddles, Young Frankenstein and The Producers in the 1960s and '70s.
Besides his classic collaborations with Brooks, Wilder paired memorably with comedian Richard Pryor in hits Silver Streak and Stir Crazy.
Wilder was also active in promoting ovarian cancer awareness and treatment after his wife, Saturday Night Live comedienne Gilda Radner, whom he married in 1984, died of the disease in 1989.
it's nice to think of Gene Wilder now back with his beloved Gilda Radner and his fellow genius Richard Pryor. RIP— Jake Tapper (@jaketapper) August 29, 2016
He helped found the Gilda Radner Ovarian Cancer Detection Center in Los Angeles and co-founded Gilda's Club, a support organization that has branches throughout the United States.
Born Jerome Silberman to Russian immigrants in Milwaukee, Wilder studied at the Bristol Old Vic Theatre in Bristol, England, and then studied method acting at the Actors Studio.
A leading role in a play that also starred Anne Bancroft, who was dating her future husband Brooks, led to Wilder becoming a top member of Brooks' stock company of crazies, some of whom branched out with Wilder into other film ventures.
Wilder's first movie role was a small part as a terrified undertaker who was abducted by Bonnie and Clyde in Arthur Penn's 1967 film of the same name.
The following year he was panic-stricken Leo Bloom to Zero Mostel's conniving Max Bialystock in Brooks' The Producers, picking up an Oscar nomination for best supporting actor. While it initially got a tepid response, the movie with its over-the-top song Springtime for Hitler, went on to become a cult favorite and, years later with a different cast, a monster hit on Broadway.
Wilder was a last-minute fill-in as the "Waco Kid" in Brooks' Blazing Saddles in 1974, and with Brooks wrote the screenplay for Young Frankenstein released later that year, also to big box office returns.
The two were nominated for best screenplay Oscars, but lost to Francis Ford Coppola and Mario Puzo for The Godfather Part II.
With Brooks alumni Madeline Kahn and Marty Feldman, Wilder made his directorial debut with 1975's The Adventures of Sherlock Holmes' Smarter Brother, and directed several other movies with uneven results.
Celebrating the wonderful silliness of Gene Wilder: The Adventures of Sherlock Holmes' Smarter Brother (opera scene) https://t.co/iEbmFm4IaP— Hubert Vigilla (@HubertVigilla) August 29, 2016
Wilder's title role in Willy Wonka and the Chocolate Factory earned him a Golden Globe nomination in 1971, and he was nominated again in that category in 1976 for "Silver Streak."
He won an Emmy in 2003 for outstanding guest actor in a comedy series for appearances on Will and Grace.
Wilder's memoir Kiss Me Like a Stranger: My Search for Love and Art was released in 2005 and he collaborated with oncologist Steven Piver on the book Gilda's Disease in 1998.
He was hospitalized in 1999 with non-Hodgkin lymphoma but was said to be in complete remission in 2005.
Wilder lived in Stamford in a house built in 1734 that he had shared with Radner, writing and painting watercolors with his wife Karen Boyer, whom he married in 1991.