Morocco was one of four regional states to normalise ties with Israel in 2020, along with Bahrain, Sudan and the United Arab Emirates.
Israeli carrier Israir has launched the first direct commercial flight between the Jewish state and Morocco since the countries normalised diplomatic relations in a US-brokered deal last year.
About 100 passengers were on the flight that departed from Tel Aviv to Marrakesh, Israir spokeswoman Tali Leibovitz said, adding that two to three flights per week were planned on the route.
Israeli Foreign Minister Yair Lapid said last week that he would visit Morocco shortly after the Israir service was launched.
The move came as former US president Donald Trump's administration recognised Morocco's sovereignty over Western Sahara, a disputed and divided former Spanish colony.
READ MORE: Will the Arab-Israeli normalisation last?
Morocco is home to North Africa's largest Jewish community, which numbers around 3,000. Some 700,000 Jews of Moroccan origin live in Israel.
Rabat had a liaison office in Tel Aviv but relations came to a halt during the 2000-2005 second Palestinian intifada, or uprising.
The normalisation deals between Arab states and Israel have been deemed a "betrayal" by the Palestinians, who say the accords ignore their rights and do not serve the Palestinian cause.