The violence came as Turkey's President Erdogan announced that a Russian delegation would arrive the following day to resume talks aimed at easing tensions in the northwest Idlib region.
At least nine civilians were killed in Ibn Semaan village of Aleppo province, war monitor SOHR says, adding 20 other civilians were killed in neighbouring provinces of Idlib and Aleppo.
Syria and Russia's assault on Idlib can trigger a domino effect of humanitarian and political catastrophes.
Local media and the Syrian Observatory for Human Rights said Syrian regime forces took control of the city of Maarat al Numan located in the northwestern province of Idlib.
Renewed violence tightened the noose around Syria's last major rebel-held bastion and deepened an already dire humanitarian crisis.
Another turning point in the hunt for Baghdadi came earlier this year during a joint operation in which US, Turkish and Iraqi intelligence agents captured senior Daesh leaders, including four Iraqis and one Syrian, an Iraqi security official says.
As children around the world start a new school year, for children in Idlib province the risks involved in going to school are increasing.
Air strikes carried out by US-led coalition forces killed and wounded many civilians, UN Commission of Inquiry on Syria's report said, adding raids by the SDF, backed by coalition gunships, also apparently violated international law.
The Syrian Observatory for Human Rights said opposition forces attacked regime positions in the south of Idlib, killing at least 51 combatants on both sides, as Russian-backed regime forces have been making gains in the last opposition stronghold.
The Syrian Observatory for Human Rights, a London-based war monitor, said that four children were among 15 civilians killed in air strikes by the Syrian regime and its ally Russia.
War monitor said that Syrian regime forces and insurgents fought fierce battles that left dozens dead in the country's northwest, as the regime tried to regain control of two villages they lost earlier this month.
Britain-based Syrian Observatory for Human Rights says the civlians, including two children, were killed on the outskirts of Maaret al Numan town and in the villages of Kansafra and Khan al Subul.
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