Stefano Tsitsipas downed Wimbldon finalist Kevin Anderson in three sets to set up a meeting on his 20th birthday with Rafael Nadal,
As the Spaniard overcame Marin Cilic it was the Greek teen Stefanos Tsitsipas who was the talking point after he defeated defending champion Alexander Zverev in three sets.
The 21-year-old German won his third title of the year and the ninth of his career by defeating Australian teen Alex De Minaur 6-2, 6-4 in the 50th edition of the US Open tuneup event.
The carnage of seeds at the world's premier grass court tennis tournament continued, with only one of the top 10 women's seeds remaining in the tournament at the fourth round.
Alexander Zverev overcame Russian in five sets while Austrian Dominic Thiem downed Japan's Kei Nishikori in four sets.
While Nadal dropped a set to win the mens titles, Elina Svitolina defended the women's title, scorching through to her title in a mere 67 minutes.
Nadal, still unbeaten in semi-finals at the Foro Italico, unleashed a trademark clay-court attack after winning a tight first set lasting well over an hour in the 51st clash between the two players.
Nadal fought back from two sets down and saved four match points in a 135-minute minute fifth set in which he successfully served to stay alive nine times, but it was not enough.
The Swiss tennis star made short work of the home crowd favourite, showing why a record breaking eighth Wimbledon title is not impossible.
Zverev broke his racket in his loss to Fernando Verdasco as Juan Martin del Potro marked his return to the tournament after five years. Seventh seed Johanna Konta tumbled out to 109th ranked Hsieh Su-Wei from Taiwan.
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