Serena Williams was relentless in her first appearance at Melbourne Park since winning the title in 2017, losing only five points in the opening set on her way to a 6-0, 6-2 win over Tatjana Maria in just 49 minutes.
Gutsy Andy Murray fought to the end before losing an epic farewell match at the hands of Roberto Bautista Agut. But it was business as usual for ruthless Roger Federer and Rafael Nadal, who joined Caroline Wozniacki in round two.
Frenchman Mouratoglou, who has guided Williams to the last 10 of her 23 Grand Slam titles, felt the American great was in “decent shape” when she reached last year’s finals at Wimbledon and the US Open.
Five-times a runner up at Melbourne Park, Andy Murray had surgery on the hip a year ago and has been unable to recover his best form.
Australian Open organisers said Serena Williams was among the entries for the opening Grand Slam of the year as she attempts to equal Margaret Court's record of 24.
Roger Federer and Serena Williams return to the tournament but hip injury forces Swiss star Andy Murray to withdraw from the championship.
Serena Williams could miss out on being named as one of the 32 seeds for Wimbledon Championships after she took maternity leave for the birth of her first child.
Despite the loss in the 29th career meeting between the two sisters, Serena, who is still shaking off the rust after a long layoff, leads their career series 17-12.
Serena Williams competes against her sister Venus in a mouth-watering Indian Wells third round showdown after her return from a 14-month absence.
Federer, the oldest No1 in history, thrashed ailing Bulgarian Grigor Dimitrov 6-2, 6-2 in a one-sided final.
After going four years without winning a major, Switzerland's Roger Federer has now won three of the last five.
More than seven years after appearing in her first Grand Slam final at the 2009 US Open, Wozniacki can finally erase the "but never won a major" footnote that has long been attached to her resume.
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