Health facilities are hit, diplomatic efforts are failing, and thousands are fleeing. The Damascus regime and its Russian allies attack northwest Syria.
Fresh killings come as rebels launch counter-offensive in western Hama province to recapture areas they lost on Thursday to regime forces. Meanwhile, aid groups suspend activities in embattled northwest.
Trump tweeted victory over Daesh and said he was pulling US troops from Syria. Turkey and Russia have welcomed the decision. France and the UK say they're staying engaged. The US withdrawal could change the balance of forces in the Syrian war.
Treasury Secretary Steven Mnuchin says the nine firms and people being added to the US blacklist are "critical actors" in a scheme to support Syrian regime leader Bashar al Assad. Officials in Moscow dismiss the sanctions as illegal.
Russian defence minister Sergei Shoigu says Moscow has delivered four S-300 launchers along with radars and support vehicles to Syria and that it will take three months to train Syrian personnel to operate the system.
Syrian state media said the country shot down five missiles; reports strikes in Hama and Tartous provinces.
Putin and Trump have agreed to pressure Iran for the sake of Israel's "security." Because of both countries' competing interests in Syria, analysts say this won't be easy.
The move comes over growing fears that member of the Syrian civil defence unit, known as the White Helmets, will be targeted by regime forces when they move into Quneitra province.
The agreement to end violence in southern Syria and surrender the crossing point with Jordan comes after rebels rejected a deal with the Russians earlier this week.
The Israeli military said its Iron Dome rocket defence system intercepted some of the incoming projectiles, while others caused only minimal damage. There were no Israeli casualties.
An advanced Russian multi-role fighter plane crashed in Syria on Thursday after take-off, killing both members of its crew, the Russian military was cited as saying by Russian news agencies.
As the US announced the new measures investigators were set to begin their work in investigating the chemical attack in Douma that prompted US-led airstrikes over the weekend.
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