Juventus had chances to win the tie but the game went into extra time and the drama was far from over, as Porto drilled home a free-kick in the 115th minute to spark wild celebrations amongst the players and coaching staff.
Inter remain four points ahead of second-placed Milan, who got back to winning ways in Rome after consecutive league losses including last weekend's derby defeat.
The rejection from the global superstar is a public relations disaster for the Kingdom which is trying to find its feet as it diversifies its economy.
CR7 is the undisputed holder of several records, the leading scorer for Real Madrid and his country, and above Lionel Messi in the Champions League goalscoring charts.
The five-time UEFA Champions League winner (four with Real Madrid, one with Manchester United) led the Portugal national team to win their first-ever major title, the UEFA Euro 2016.
Robert Lewandowski scored a dramatic injury-time winner, his second goal of the game, to earn Bayern Munich a 2-1 comeback victory against Bayer Leverkusen.
The Bayern Munich forward has been named The Best FIFA Men's Player 2020, beating off competition from last year's winner Lionel Messi and Cristiano Ronaldo.
With the victory over Spezia, Juventus end a run of three consecutive draws to move to third place in Italy's Serie A football league.
The match would have been the first time Ronaldo faced his personal rival Lionel Messi since he left Real Madrid in 2018.
Portugal captain, Cristiano Ronaldo shot back at Italy's sports minister by denying that he broke the coronavirus protocol adopted for the country's football after returning from international duty while positive for the disease.
The 35-year-old Juventus striker will miss Wednesday's UEFA Nations League game against Sweden but is "well, has no symptoms and is in isolation", the Portuguese federation says.
A goal up after winning February's first leg, French side Lyon will face Manchester City at the final tournament in Lisbon after drawing 2-2 on aggregate and going through on away goals.
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