Eastern Ghouta was the opposition's final stronghold on the edge of Damascus, but beleaguered opposition groups are now left with less than 10 percent of their one-time bastion.
Pakistani national Muhammad Akram and his wife Sighra Bibi escaped eastern Ghouta, leaving behind several family members, including Akram's children from his second wife, who was a Syrian.
Assad regime forces continue to target civilians in opposition-held enclave in open defiance of truce.
The Syrian Observatory for Human Rights says civilians were killed in Douma, the largest town of the opposition-held enclave near Damascus.
The Syrian Observatory for Human Rights says regime strikes killed over 30 civilians in eastern Ghouta's Zamalka town as people were preparing to flee the enclave.
At least 12,500 people have left the opposition-held enclave near Damascus as the regime army and its allies continue to launch air strikes and shell the area.
Syrian regime leader Bashar al Assad controls 58 percent of Syria, according to a monitor. The war has killed half a million people and seen the deadliest use of chemical weapons since the 1980s.
Twelve members of the Failaq al Rahman opposition group in eastern Ghouta, including two of its commanders, have been killed according to the Syrian Observatory for Human Rights.
An oppositon group announced that it had reached a medical evacuation deal with the Syrian regime's key ally, Russia, after indirect talks.
US Ambassador to the United Nations Nikki Haley says Washington is prepared to act if the Security Council fails to prevent the Syrian regime's chemical attacks, which are killing and wounding civilians.
As Syrian regime's Russian-backed assault on eastern Ghouta enters fourth week, key figures in an opposition-held town evacuation offer. But opposition groups in enclave vow they will fight on.
The Syrian regime forces have cut off the two large eastern Ghouta towns of Douma and Harasta by advancing into areas between them and the rest of the opposition enclave, a war monitor says.
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