A win against Deportivo La Coruna allows Barcelone to secure their 25th La Liga title, and first since 2016, with four games to spare.
Barcelona is only the third team in the tournament's history to have won four successive tournaments on the trot.
The pair of own goals by Daniele De Rossi and Kostas Manolas plus some sloppy defending that allowed Gerard Pique and Luis Suarez to also score left Roma on the verge of elimination.
The win over Girona was Barcelona's 32nd league game without a loss after going undefeated through all 25 rounds this season under Ernesto Valverde plus the last seven from the last campaign under Luis Enrique.
After producing a sensational comeback from two goals down to beat Real Sociedad 4-2 on, Barcelona sit nine points clear at the top of La Liga.
Barcelona agrees to sign Liverpool star Philippe Coutinho for $192 million in the third most expensive deal of all time.
Barca top the standings with 22 points but their lead over Real Madrid was cut to five as Zinedine Zidane's side moved above Atletico, who are third on 16, after winning 2-1 at Getafe earlier on Saturday.
The most coveted prize in European club football started with a bang on its first night with a total of 28 goals being scored.
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