The first air strike wounded two people but the second was deadly, with rescuers among those killed in Mekele, the capital of Tigray region.
The government and Tigray rebels have traded blame for initiating a military escalation that ended a five-month ceasefire.
The hospital in the town of Shire where victims were taken reported at least 55 people dead and 126 injured, according to an official in Tigray's capital Mekele.
“Reports of deadly air strikes on the Tigrayan regional capital Mekele were an 'absolute lie' by the Tigray People’s Liberation Front,” said Legesse Tulu, head of the Government Communication Service.
"Some 18,600 children under the age of five in Tigray have been admitted for treatment for severe acute malnutrition from February to August this year compared to 8,900 in 2020, a 100% increase," says UN.
The reports of a fresh offensive come despite mounting international criticism of the brutal near 11-month conflict in the north of the country.
Spokesman for Tigray People's Liberation Front says they carried out operations against special forces and militia fighters from Oromia region, Ethiopia's largest, who were massing along the Tigray-Afar border.
Acting UN aid chief Ramesh Rajasingham says some 1.8 million people are on the brink of famine and 33,000 children are severely malnourished as brutal conflict grinds on in Tigray region.
A bridge over the Tekeze River that’s crucial to delivering desperately needed food to much of Ethiopia’s embattled Tigray region has been destroyed.
Witnesses say Tigrayan rebels entered Ethiopia’s key northern town of Shire, cementing further territorial gains in the northern region of Tigray
Blitz on a busy market comes amid some of the fiercest fighting in Tigray since the conflict began as Ethiopian forces supported by those from neighbouring Eritrea pursue Tigray’s former leaders.
Eritrea denies allegations of aid obstruction but Abiy government's documents suggest soldiers have been plundering food supplies, stoking fears of starvation deaths, and blocking access to Ethiopian checkpoints.
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