Federer, a seven-time champion, was ousted from one of his favourite tournaments in barely over an hour, falling in straight sets to a 21-year-old Andrey Rublev he had never faced.
Never before has a final in London lasted so long - it went into the twelfth game of the fifth set and then into the tiebreak.
The most captivating modern rivalry in men's tennis returns to the scene of its most dramatic episode when Roger Federer and Rafael Nadal meet for a place in the Wimbledon final.
Federer and Nadal each won their quarter-finals to set up an epic semi-final between the two, whilst world number 1 Djokovic will face Bautista Agut for a place in the final.
Cheesemaker Slobodan Simic says Serbia's one-of-a-kind donkey cheese is not only tasty but also good for your health.
Tsitsipas had never won a set in his previous three meetings against claycourt specialist and 11-times French Open champion Nadal, but the Greek drew first blood by saving a break point to hold in the 10th game and take the first set.
An erratic Novak Djokovic suffered a surprise 6-3, 4-6, 6-2 defeat against the 10th-seeded Russian Daniil Medvedev in the Monte Carlo Masters quarter-finals.
Failing to win his 850th match, the top seed Serb lost to 22nd-seeded Roberto Bautista Agut 1-6, 7-5, 6-3.
Swiss player Roger Federer overcomes Stefanos Tsitsipas 6-4 6-4 in Dubai final.
World number one tennis player Novak Djokovic crowned a winning return to the courts after surgery with the Laureus sportsman of the year award, while American gymnast Simone Biles won the sportswoman of the year prize.
With his seventh victory from as many finals at Melbourne Park, the 31-year-old Serb moved past Roger Federer and Roy Emerson, who have six Australian Open titles each.
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