The club said last week that striker Gabriel Jesus and defender Kyle Walker tested positive but manager Pep Guardiola refused to divulge the names of the other "three important players" who would not be available for Sunday's match.
Sergio Conceicao's side were on the defensive for long periods at the Estadio do Dragao, but a series of superb saves from Porto keeper Agustin Marchesin secured the point they needed to advance.
Joe Willock scores Arsenal’s winning penalty to set up a home match against defending champion Manchester City in the next round.
Manchester City Football Club had not conceded five goals in a home game since 2003 against Arsenal and it was the first time their boss Pep Guardiola saw a side he is managing concede five in what was his 686th game in the dugout.
In February, Spain’s Cadena Ser radio network reported that a company hired by Barcelona used fake social media accounts to discredit opposition figures and even some of its players when they expressed views that went against the club.
Gabriel Jesus scored an equaliser in the 78th minute and Kevin De Bruyne netter an 83rd-minute winner from the penalty spot as Man City came from behind for a 2-1 win over Madrid in the first leg of the last 16 at the Bernabeu Stadium on Wednesday.
The league leaders won the FIFA Club World Cup title last Saturday, take on second-placed Leicester City on Thursday and host Wolverhampton Wanderers on Sunday, but other teams including Manchester City are not as fortunate.
Arteta, who made 149 appearances for Arsenal between 2011 and 2016 before joining Manchester City's coaching staff as Pep Guardiola's assistant, replaces fellow Spaniard Unai Emery at the Emirates Stadium.
Thirteen-time winners Real Madrid were drawn against English champions Manchester City while title-holders Liverpool must face Diego Simeone's Atletico Madrid in the Champions League round of 16 following Monday's draw.
Liverpool will be seeking its sixth European title when it faces fellow English club Tottenham on Saturday in Madrid.
Santiago Solari marks his 100th day in charge of Real Madrid with a 1-1 draw at Barcelona in the Copa del Rey, 101 days after his predecessor's reign ended with a 5-1 thrashing to the Catalans.
The foundations are being laid for one of the English Premier League's most exhilarating and competitive title races. For the first time since the league's inception, Chelsea and Liverpool have a 100 percent winning record in their first five games.
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