Chelsea says it has been a "very difficult decision" to part ways with the 42-year-old, who replaced Maurizio Sarri in July 2019.
The warning to adhere to Covid-19 guidelines in football comes while a more contagious variant of Covid-19 is sweeping across Britain.
Aston Villa were forced to field academy players due to a mass Covid-19 outbreak among their ranks, with Under-23 coach Mark Delaney taking charge of the game instead of first-team manager Dean Smith.
Since the new season kicked off, 171 individuals in the English top-flight have tested positive for the novel coronavirus from 19 rounds of testing.
Liverpool fell behind to a second-minute lob by former striker Danny Ings and had a penalty claim dismissed when Georginio Wijnaldum's shot from inside the box was blocked by the hand of Jack Stephens.
Coach Mauricio Pochettino was manager of Tottenham in the Premier League for five years and led the Spurs to the Champions League final in 2019.
The club said last week that striker Gabriel Jesus and defender Kyle Walker tested positive but manager Pep Guardiola refused to divulge the names of the other "three important players" who would not be available for Sunday's match.
Several managers have suggested a pause would take the pressure off clubs, but the Premier League says it has no plans to do so.
A record 18 positive tests for Covid-19 among players and staff were detected in the weekly round of testing in the Premier League.
Meanwhile, Arsenal have eased fears of being dragged into a relegation battle with a stunning 3-1 win over Chelsea, as Manchester United's Premier League title challenge stumbled after they conceded a late equaliser to draw at Leicester.
Mo Salah told Spanish newspaper AS in an interview this month that he admired Real Madrid and Barcelona, fuelling talk in the British media that he was looking to move on.
City ensured it will be a miserable Christmas for beleaguered Arsenal boss Arteta by condemning his side to a fourth defeat in their last six games in all competitions.
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