Roger Federer is out of the US Open after losing to John Millman. It was Federer's first loss against a player outside the top 50.
Five-time champion Roger Federer beat Australian Nick Kyrgios in three sets and reached the US Open last 16 while Slovakia's Dominika Cibulkova took out Wimbledon champion Angelique Kerber.
The last time the Swiss tennis star lifted the trophy was back in 2008 and he he has twice made the finals since, but the title at Flushing Meadows has eluded him ever since.
Djokovic, who had come off second best in five previous Cincinnati finals, defeated seven-time winner Roger Federer 6-4, 6-4 in the final.
The 21-year-old German won his third title of the year and the ninth of his career by defeating Australian teen Alex De Minaur 6-2, 6-4 in the 50th edition of the US Open tuneup event.
South Africa's Kevin Anderson became the first South African to reach the Wimbledon final in 97 years after triumphing over John Isner in the tournament's second longest match.
South African Kevin Anderson's hopes looked forlorn as Federer skipped through the opening two sets on Court One with his usual panache, but he turned the match on its head to cause the biggest shock yet in a tournament full of upsets.
Tennis fans are dreaming of another final between Rafael Nadal and Roger Federer as the two have stormed into the Wimbledon quarterfinals on 'manic Monday', when all 16 fourth-round singles matches are played.
The carnage of seeds at the world's premier grass court tennis tournament continued, with only one of the top 10 women's seeds remaining in the tournament at the fourth round.
Defending champion Roger Federer defeats Lukas Lacko while sisters Serena Williams and Venus Williams advance to the next round. Meanwhile, world number two Caroline Wozniacki suffers shock defeat against Ekaterina Makarova.
Seven-time winner Serena Williams, who missed the tournament last year, faces Bulgarian qualifier Viktoriya Tomova.
Roger Federer and Serena Williams return to the tournament but hip injury forces Swiss star Andy Murray to withdraw from the championship.
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