Chelsea beat Leeds United 3-1 in front of 2,000 spectators at Stamford Bridge while Manchester United fought back from a goal down to win 3-1 at West Ham United.
Tuesday's action in the Champions League saw Erling Braut Haaland, Neymar, Cristiano Ronaldo and Bruno Fernandes all get among the goals.
Javi Martinez headed in the winning goal in extra time as Bayern Munich beat Sevilla 2-1 in the UEFA Super Cup in a stadium partially filled with fans.
Sevilla clinched the Europa League title with a 3-2 win over Inter Milan after an overhead kick by defender Diego Carlos deflected by the Italian side's top scorer Romelu Lukaku settled a thrilling contest.
The Spanish club, Sevilla have now won 25 of their last 26 Europa League knockout ties and may be destined to win the competition for a sixth time when they face Inter Milan or Shakhtar Donetsk in the final.
Alvaro Morata scored twice to help Atletico Madrid to a 3-0 win over relegation-haunted Mallorca and stretch their unbeaten La Liga run to 12 games, as the victory consolidated their third place on 62 points to stay well on course.
The second of Europe's five major leagues, La Liga, kicked off in Spain as two local rivals, Sevilla and Real Betis met in a hotly contested derby behind closed doors.
Reyes, who shot to fame at Sevilla before a switch to Arsenal followed by spells at Real and Atletico Madrid, was on the books with second tier Spanish club Extremadura.
Forty-six-year-old Spaniard, Unai Emery, had previously been manager at Paris St Germain and Sevilla.
The draw for the quarter-finals of the UEFA Champions League took place at UEFA headquarters in Nyon, Switzerland on Friday.
Manchester United suffers a shock exit in the last 16 after Sevilla substitute Wissam Ben Yedder strikes twice at Old Trafford.
Spanish outfit Sevilla eliminated Istanbul Basaksehir from entering the Champions League this season after beating them 4-3 on aggregate over two qualifying matches.
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