The Syrian regime killed at least 186 children in chemical attacks, the Syrian Network for Human Rights said. Another 305 children died of malnutrition and medicine shortages in the areas besieged by the regime.
Hospitals are struggling to keep intensive care equipment running, leaving the parents of vulnerable children with nowhere to turn to.
Portugal and Real Madrid footballer Cristiano Ronaldo has shared an inspirational message on Twitter in support of Syrian children.
Since Jarablus was cleared of Daesh 12 months ago, the city is slowly rebuilding but faces many challenges.
The children, aged between seven months to 17 years, require immediate evacuation for conditions that include kidney failure, severe malnutrition and conflict wounds, the United Nations children's agency says.
With a third of the schools in the country rendered unusable as the civil war in the country rages on, Syrian children have paid the heaviest price in the conflict.
A UNICEF report says children are dying in record numbers as the six-year conflict drags on in Syria, decimating the country's most vulnerable generation. Children are also being recruited to fight in record numbers.
Syrian activists have taken the Pokemon Go craze to bring much needed awareness to the plight of children in war-torn Syria.
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