US authorities say at least seven people, including two children, died in Des Moines town and Lucas County.
Each year, the US gets around four times as many twisters as the rest of the world combined.
About 26,000 homes and businesses were without electricity across the US state of Kentucky as residents faced gas and water outages after infrastructure was damaged.
The crash on an interstate highway near the city of Greenville involved at least 15 vehicles and was "probably" caused by hydroplaning under torrential rains, Butler County coroner Wayne Garlock said.
It wasn't clear whether the combination of destroyed housing and social distancing requirements due to Covid-19 outbreak would lead to problems for tornado survivors, some of whom said they planned to stay with relatives.
Mississippi Emergency Management Agency director Greg Michel said one person killed was in Walthall County, two were killed in Lawrence County and three were killed in Jefferson Davis County.
Voting hours were extended due to the devastation the twisters wrought when they touched down shortly after midnight. Rubble was strewn across the state capital Nashville.
Storm-related fatalities were reported in Texas due to icy weather, in Alabama from a deadly tornado and in Louisiana, where winds were so strong that a trailer home was lifted off its foundation and carried several hundred feet.
Storms trigger multiple tornado watches and warnings over a span of several hours Monday with the The National Weather Service saying that the severe weather threat could last into the early hours Tuesday.
After several quiet years, tornadoes have erupted in the US over the last two weeks as a volatile mix of warm, moist air from the southeast and persistent cold from the Rockies clashed and stalled over the Midwest.
Ohio residents inspected destroyed homes and debris-strewn streets after powerful tornadoes ripped through the US state overnight, killing at least one person and causing widespread damage and power outages.
The three deaths and several injuries were recorded in and around Golden City, Missouri, where a tornado touched down on Wednesday. The casualties bring the week's weather-related death toll to at least seven.
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