Hundreds of thousands of civilians have been killed or displaced in the conflict, mainly by regime airstrikes targeting opposition-held areas.
Three months ago, UN Chief Antonio Guterres announced a series of breakthroughs, which are apparently yet to come into effect as a new UNICEF report says at least eight children are still killed or injured in Yemen every day.
A centre in Turkey's capital is looking to provide refugee children with the tools they need to build a new life.
Around 103 babies out of 1,000 live births die in Nigeria's Masaka town.
Sandwiched between Syria and Jordan, eight children died at the refugee camp in the last month alone, as a result of both the Assad regime and Jordanian government sealing the border, blocking medical and food supplies.
Pakistan spends less than one percent of its GDP on health and experts say that's kept the high infant mortality rate from improving.
Several thousand children in this region have been declared witches who are 'possessed by evil spirits' but the government is unable to curb the practice, fearing a political backlash.
A new UN report indicates that thousands of children, mostly boys, have been recruited by the armed groups and thousands of more, most of them girls, are sexually exploited and abused during the five years of fighting in Central African Republic.
UNICEF warns that the number of 18.5 million people who are unsure of where their next meal is coming from may soon dramatically increase.
More than 11 million children face threat of food shortages, disease, displacement and acute lack of access to basic social services.
In Turkey's border town of Kilis, a judo tournament bring some joy into the life of refugee children who are coping with severe hardships.
The use of rape by Myanmar's armed forces has been sweeping and methodical, although the military has denied its soldiers raped any Rohingya women. Now, the babies conceived during those assaults have been born.
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