Research shows for the first time how measles – one of the world's most contagious diseases – erases the body's memory of previous pathogens, effectively wiping its immunity memory.
Measles, the contagious childhood disease that is once more on the rise globally, is more harmful than previously thought.
A new analysis of 77 unvaccinated children from the Netherlands carried out by an international team of researchers led by scientists at Harvard has found that the virus erases the body's memory of previous pathogens – effectively wiping its immunity memory.
The virus eliminated between 11 and 73 percent of the children's protective antibodies, blood proteins responsible for "remembering" previous encounters with disease, the team wrote in the journal Science on Thursday.
This left some of the children with immunity close to that of a newborn baby.
"It sort of resets your immune system back to sort of a more naive state," said Harvard epidemiologist and coauthor Michael Mena.
In order to rebuild their defences, they will need to be exposed to numerous pathogens as they were in their infancy, he added.
To validate their result, the team then carried out experiments on macaque monkeys and found that the animals lost 40 to 60 percent of their protective antibodies.
"The virus is much more deleterious than we realised, which means the vaccine is that much more valuable," said study co-author and Howard Hughes Medical Institute Investigator Stephen Elledge.