Israeli forces raided Assem Barghouthi’s house in the town of Kobar in the central West Bank and destroyed it with bulldozers.
Israeli forces demolished the home of a Palestinian man on Thursday who has been accused of killing two Israeli soldiers in an armed attack.
Violence erupted when Palestinians tried to stop the Israeli soldiers, who attacked them with both live and rubber bullets and tear gas.
Israeli authorities accuse Assem Barghouthi of killing two soldiers and injuring eight settlers in two shooting attacks in the West Bank last year.
He was arrested by Israeli forces on January 8 after a month-long manhunt.
His brother, Saleh, was shot dead by Israeli forces in December for his alleged involvement in a shooting attack.
In February, the Israeli army said it would demolish the two brothers’ homes for their alleged involvement in attacks against Israeli targets.
They later detained Barghouthi's mother, Suheir Barghouthi.
Israel uses the emergency law of the British Mandate in 1945 to demolish Palestinian homes whose owners allegedly carried out attacks against Israelis.
Israel’s top court usually rejects Palestinians' appeals against the demolition of their homes.