The former Minneapolis police officer is charged with two counts of depriving Floyd of his rights during the last year's arrest that resulted in his death, sparking worldwide protests.
White former Minneapolis police officer Derek Chauvin ahs pleaded guilty in a federal court in Minnesota to charges he violated George Floyd's civil rights during the Black man's murder, reversing his not-guilty plea in September.
Chauvin, 45, entered his guilty plea in the US District Court on Wednesday.
He faces a maximum penalty of life imprisonment, although an agreement to plead guilty could result in prosecutors asking for a lighter sentence.
Chauvin's lawyer Eric Nelson did not respond to a request for comment on Tuesday.
Prosecutors have not indicated any intent to seek the death penalty.
Chauvin has already been sentenced to 22-1/2 years in prison in state court for the 2020 murder of Floyd, on whose neck the then-policeman knelt for nearly nine minutes while a bystander captured it on her cellphone.
His April conviction in state court, on charges of unintentional second-degree murder, third-degree murder and manslaughter, was seen by many as a landmark rebuke of the disproportionate use of police force against Black Americans.
The video showed Chauvin kneeling on the neck of the handcuffed Floyd for more than nine minutes during the arrest caused global outrage – and triggered one of the biggest protest movements in the United States in decades.
Chauvin and three other officers – Thomas Lane, J. Alexander Kueng and Tou Thao – were arresting Floyd on suspicion of using a fake $20 bill.
Lane, Kueng, and Thao face charges in a state trial due to begin in March that they aided and abetted the killing of Floyd.
In addition to the state charges, all four officers were federally indicted in May on charges of depriving Floyd of his civil rights by failing to provide him with medical attention.
Chauvin also was federally charged with violating Floyd's right to be free from unreasonable seizure and unreasonable force by a police officer.
Thao and Kueng were federally charged with violating Floyd's right to be free from unreasonable seizure by not intervening to stop Chauvin from kneeling on Floyd's neck.
Chauvin has also pleaded not guilty to federal charges of violating the civil rights of a 14-year-old boy he arrested in 2017.