Calderon, who died aged 93, was last person in world who could speak Yagan community's language and also created its dictionary with translations to Spanish.
An indigenous language from South America's extreme south has all but vanished after the death of its last living speaker and guardian of its ancestral culture.
Cristina Calderon died on Wednesday, aged 93.
She had mastered the Yamana language of the Yagan community and after the death of her sister in 2003 was the last person in the world who could speak it.
She worked to save her knowledge by creating a dictionary of the language with translations to Spanish.
"With her, an important part of the cultural memory of our people is gone," said Lidia Gonzalez, Calderon's daughter, on Twitter.
Gonzalez is one of the representatives currently drafting a new constitution in Chile.
The dictionary, however, meant there was the hope of preserving the language in some form, she said.
[DECLARACIÓN PÚBLICA]— Lidia González Calderón (@lidiayagan) February 16, 2022
Sobre el fallecimiento de mi madre, Cristina Calderón
Hoy, jueves 16 de febrero de 2022, falleció mi madre, depositaria de nuestras tradiciones, última hablante activa del Yagán. Con ella se va parte importante de la memoria cultural de nuestro pueblo
Calderon lived selling socks
"Although with her departure a wealth of especially valuable empirical knowledge is lost in linguistic terms, the possibility of rescuing and systematising the language remains open," she said.
Although there are still a few dozen Yagans left, over the generations people from the community stopped learning the language, which was considered "isolated" since it was difficult to determine the origin of its words.
Calderon lived in a simple house and made a living selling knitted socks in the Chilean town of Villa Ukika, a town created by the Yagan people on the outskirts of Puerto Williams.
The ancestral ethnic group used to populate the archipelagos of South America's extreme south, now Chile and Argentina, an area that nudges towards the frozen Antarctic.