Nigeria's health system could come under immense stress as it faces a two-pronged fight.
The motive for the murder in the town of Lwemba in the troubled Ituri region was unknown, but it came as health authorities were set to introduce a new vaccine against the disease in unaffected areas.
Democratic Republic of Congo recorded 2,382 cases of Ebola, of which 1,606 were fatal, the Health Ministry says.
People in parts of the Democratic Republic of the Congo have linked the response to the Ebola outbreak with political disenfranchisement making it harder for foreign organisations to contain the outbreak.
Victim was the grandmother of a five-year-old boy who died on Tuesday after crossing into Uganda with his family from the Democratic Republic of Congo.
A 5-year-old boy vomiting blood becomes the first cross-border victim of Ebola in the current outbreak, while two more people in Uganda test positive for the highly contagious disease that has killed nearly 1,400 in Democratic Republic of Congo.
A World Health Organization expert says the UN body expects continued "intense transmission" of Ebola virus in Congo with community mistrust being a major issue in some areas.
Traditional ceremonies in Madagascar where families re-wrap the remains of dead relatives pose a serious risk of plague contamination. Since August, the disease has infected more than 1,100 people, with 124 deaths.
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