Organisers say 34-year-old Novak Djokovic, who had repeatedly declined to reveal his vaccination status, applied for a medical exemption, which was granted after a "rigorous review process".
Djokovic so far has declined to disclose his vaccination status amid local media reports that everyone on the entry list needed to be vaccinated or have a medical exemption.
Naomi Osaka has struggled for form after withdrawing from French Open in May after a row with tournament officials over required media appearances.
Medvedev, playing in his third major final, at last hoisted a Grand Slam trophy while avenging a straight sets defeat by Djokovic earlier this year in the Australian Open final.
Emma Raducanu has become the youngest Grand Slam champion in 17 years, ending the tournament as the first player since Serena Williams in 2014 to not drop a set in the US Open.
One more victory will give the 34-year-old Djokovic the first calendar-year Slam since Rod Laver accomplished it 52 years ago.
Emma Raducanu, an 18-year-old from Britain who is ranked 150th, and Leykah Fernandez, a 19-year-old from Canada who is ranked 73rd, will clash in first Grand Slam final between teens since 1999.
World number one Novak Djokovic admits that his exertions in Japan have taken their toll after pulling out of the Tokyo Olympics due to a shoulder injury.
Serbian tennis player Novak Djokovic breaks Roger Federer's record for most weeks as the men's top number one, and plans to win many more Grand Slams.
Tennis Australia CEO Craig Tiley said the successful completion of the Australian Open despite the ongoing pandemic can serve as a blueprint for other sports.
The novel coronavirus pandemic has infected more than 100 million people around the world, with over 2.1 million fatalities. Here are updates for January 27:
The ATP said the men’s qualifying for the season’s first Grand Slam tournament is being moved to Doha, Qatar, from January 10-13.
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