The underwhelming performance of the reigning champions will most likely require them to beat Rafael Nadal's Spain to stand a chance of reaching the knock out phase.
Stefano Tsitsipas downed Wimbldon finalist Kevin Anderson in three sets to set up a meeting on his 20th birthday with Rafael Nadal,
As the Spaniard overcame Marin Cilic it was the Greek teen Stefanos Tsitsipas who was the talking point after he defeated defending champion Alexander Zverev in three sets.
Tennis fans are dreaming of another final between Rafael Nadal and Roger Federer as the two have stormed into the Wimbledon quarterfinals on 'manic Monday', when all 16 fourth-round singles matches are played.
Alexander Zverev overcame Russian in five sets while Austrian Dominic Thiem downed Japan's Kei Nishikori in four sets.
Murray will now face Kei Nishikori from Japan, while Stan Warinka will find himself up against Marin Cilic. The victory was Murray's 650th career win.
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