Sunni majority Syria was carved out of Ottoman Turkey in 1945, but since 1970, the Assad clan from an Alawite minority has ruled over it.
The Britain-based Syrian Observatory for Human Rights said the missiles hit positions belonging to Iran and its regional proxies.
Israel says it launched the strikes in retaliation to rockets being fired into Israel from Syria. The rocket fire comes a week after an Israeli airstrike had killed family members of Palestinian militant in Syria.
Syrian regime and its ally pummel contested towns with more than 600 air strikes in 15 hours, a war monitor says, following collapse of Russian-brokered talks to end the offensive in Daraa province.
The US missile strikes offer no guarantee if they will cause serious damage to Bashar al Assad’s chemical weapons infrastructure.
If Turkey wants to succeed in Afrin it will need to achieve its objectives before Russia is encouraged to make a deal with the YPG that can undermine, or effectively end, the operation.
Women and children were among those killed by airstrikes on a rebel-held village in northwestern Idlib province, the Britain-based Syrian Observatory for Human Rights said on Wednesday.
The armed forces confirmed they had begun a reconnaissance mission in Syria's Idlib province on Sunday.
Militant leader Abu Mohammad al Golani, the former head of the Nusra Front before it merged with other groups to form Tahrir al Sham, was injured in an air strike.
Air strikes kill two people at the facility in western Mysaf town where the regime has been accused of developing chemical weapons.
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