Assad can face a future where he has no card left to play.
The UK-based Syrian Observatory for Human Rights said Israeli strikes on a military base run by Iranian-backed Lebanese Hezbollah caused the series of blasts.
Families without shelter in Syria have been forced to camp out in their cars, sleep in schools or mosques, or even make home in an abandoned prison.
Regime forces backed by Russia, and Iranian militias capture 13 villages and small towns in Aleppo province, a war monitor says. Separately, car blast targets civilians in northern Tal Abyad town.
Turkey warned that the advances by Russian-backed Syrian regime forces and their allies threaten a fresh humanitarian disaster in Syria's northwestern Idlib province.
"We fully support Turkey’s justified self-defence actions in response" to attacks, said US Secretary of State Mike Pompeo.
Experts say the contact is symbolically important but wouldn’t change much on the ground as Turkey and Russia are still on opposite sides over Idlib.
An intensified bombardment by Russian forces and the Syrian regime has pushed thousands of people to flee to the border with Turkey, residents and rescue workers are saying.
The air raids in the militant-run northwestern region of Idlib also wounded several others, the Syrian Observatory for Human Rights says.
The Syrian regime and Russia were under the impression that the YPG is on the ropes, but that turned out to be a strategic miscalculation as the YPG is still unwilling to make major concessions. This means the YPG-Syrian regime deal is falling apart.
The explosion happened near a local hospital in Cobanbey town. No group has yet claimed responsibility for the attack.
The opposition and rebel withdrawal came after the Russia-backed Syrian regime forces advanced into Khan Shaykhun city in Idlib. The US urged the regime to revert to a ceasefire in Idlib after Monday's air strike on a Turkish convoy.
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