The violence came as Turkey's President Erdogan announced that a Russian delegation would arrive the following day to resume talks aimed at easing tensions in the northwest Idlib region.
At least nine civilians were killed in Ibn Semaan village of Aleppo province, war monitor SOHR says, adding 20 other civilians were killed in neighbouring provinces of Idlib and Aleppo.
Syria and Russia's assault on Idlib can trigger a domino effect of humanitarian and political catastrophes.
Local media and the Syrian Observatory for Human Rights said Syrian regime forces took control of the city of Maarat al Numan located in the northwestern province of Idlib.
Britain-based Syrian Observatory for Human Rights says heavily-bombarded Maarat al Numan "is nearly besieged," with residents of several villages scurrying for safety in the northwest of the country.
Idlib has come under mounting bombardment in recent weeks, displacing tens of thousands of people in the northwestern province, despite a truce brokered by Turkey and Russia.
A new cessation of hostilities agreement between Russia and Turkey, who support the opposite sides in the conflict, went into effect last week but violence has continued.
With regime forces renewing attacks on rebel-held Idlib in northern Syria, the pact between Ankara and Moscow to build peace in the region is constantly being violated, putting an enormous strain on their bilateral ties.
Another turning point in the hunt for Baghdadi came earlier this year during a joint operation in which US, Turkish and Iraqi intelligence agents captured senior Daesh leaders, including four Iraqis and one Syrian, an Iraqi security official says.
Syrian regime and Russian forces have killed at least six civilians in northwestern Idlib province, according to a war monitor.
Air strikes carried out by US-led coalition forces killed and wounded many civilians, UN Commission of Inquiry on Syria's report said, adding raids by the SDF, backed by coalition gunships, also apparently violated international law.
The Syrian Observatory for Human Rights said opposition forces attacked regime positions in the south of Idlib, killing at least 51 combatants on both sides, as Russian-backed regime forces have been making gains in the last opposition stronghold.
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