Khost, a restive Afghan province bordering Pakistan, is home to members of the Taliban and also Al Qaeda militants, officials say. No group has so far claimed responsibility for the attack.
Abu Muhsin al Masri was on FBI's Most Wanted list and the announcement of his killing came hours after a suicide bombing at an education centre in Kabul killed at least 18 people and wounded dozens more.
The suicide attack happened late afternoon at the centre, which offers training and courses for students in higher education in a western district of Kabul.
At least 25 personnel have been killed, according to the Takhar governor's spokesperson, but some accounts put the death toll as high as 50.
Afghan officials say the attack took place in Afghanistan's western Ghor province targeting government buildings, adding the death toll is expected to rise.
In a blow for the embattled government, two defence force helicopters setting off for a military mission in Helmand have crashed into each other, killing nine people on board.
The air strikes, carried out over the last two days, mark a rare military intervention by the United States since it signed an agreement on troop withdrawal with the Taliban in February.
Car bomb targets government building in Ghani Khel district of eastern Nangarhar province, killing at least 15 people and wounding nearly 40 others, officials say.
Abdullah Abdullah, chairman of Afghanistan's High Council for National Reconciliation that is overseeing Kabul's peace push, said after several small-group meetings in Doha, the issue had been resolved "to a large extent."
At least 14 civilians have been killed by a roadside bomb in central Afghanistan, officials say.
Afghanistan's top official in negotiations with the Taliban, Abdullah Abdullah, meets Pakistani officials in Islamabad, in talks aimed at ending decades of war and a reset of bilateral ties.
Afghanistan today stands at a turning point.
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