The motive for the murder in the town of Lwemba in the troubled Ituri region was unknown, but it came as health authorities were set to introduce a new vaccine against the disease in unaffected areas.
The mosquito-borne viral infection, that is found in tropical countries worldwide, kills dozens of people every year in Pakistan.
Democratic Republic of Congo recorded 2,382 cases of Ebola, of which 1,606 were fatal, the Health Ministry says.
People in parts of the Democratic Republic of the Congo have linked the response to the Ebola outbreak with political disenfranchisement making it harder for foreign organisations to contain the outbreak.
Victim was the grandmother of a five-year-old boy who died on Tuesday after crossing into Uganda with his family from the Democratic Republic of Congo.
A 5-year-old boy vomiting blood becomes the first cross-border victim of Ebola in the current outbreak, while two more people in Uganda test positive for the highly contagious disease that has killed nearly 1,400 in Democratic Republic of Congo.
A World Health Organization expert says the UN body expects continued "intense transmission" of Ebola virus in Congo with community mistrust being a major issue in some areas.
The World Health Organization said on Tuesday that the Ebola outbreak in Democratic Republic of Congo could deteriorate rapidly because of attacks by armed groups, community resistance and the geographic spread of the disease.
The latest flare-up comes one week after DRC's government declared the end of another outbreak that is believed to have killed as many as 33 people. There are 13 confirmed cases.
According to the World Health Organization, the mosquito-borne disease kills 600,000 people worldwide every year.
The new bed net has a special chemical that blocks mosquitoes resistance to insecticides and in a test has proven to cut malaria prevalence by as much as 44 percent.
Sleeping sickness, Chagas disease and Leishmaniasis kill thousands each year but little funding has been put into their study so far.
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