Naomi Osaka has struggled for form after withdrawing from French Open in May after a row with tournament officials over required media appearances.
Medvedev, playing in his third major final, at last hoisted a Grand Slam trophy while avenging a straight sets defeat by Djokovic earlier this year in the Australian Open final.
Emma Raducanu has become the youngest Grand Slam champion in 17 years, ending the tournament as the first player since Serena Williams in 2014 to not drop a set in the US Open.
One more victory will give the 34-year-old Djokovic the first calendar-year Slam since Rod Laver accomplished it 52 years ago.
Emma Raducanu, an 18-year-old from Britain who is ranked 150th, and Leykah Fernandez, a 19-year-old from Canada who is ranked 73rd, will clash in first Grand Slam final between teens since 1999.
World number one Ash Barty crashes out of US Open, losing 6-2 1-6 7-6(5) to 43rd-ranked American Shelby Rogers, in biggest upset of tournament thus far.
Naomi Osaka's title defence was over in third round with a 5-7, 6-7 (2), 6-4 loss to Leylah Fernandez, an 18-year-old from Canada who is ranked 73rd and never had been this far in Grand Slam competition.
Serena Williams has had an injury-marred season and limped out of her first-round match at Wimbledon in tears due to the leg injury.
World number-two ranked Daniil Medvedev of Russia beat John Isner of the United States 6-2, 6-2 in the National Bank Open semifinals to face American Reilly Opelka in the final.
World number one Novak Djokovic admits that his exertions in Japan have taken their toll after pulling out of the Tokyo Olympics due to a shoulder injury.
Saso won the title with a 10-foot putt on the ninth hole to become the first player from the Philippines to win a golf major.
Electronic line calling technology was also deployed at the Australian Open, a move largely welcomed by players.
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