The mother and one of her children were already dead when rescuers pulled them out, while two children succumbed to their wounds shortly afterward, White Helmets say.
The Moscow-Damascus alliance often carries out indiscriminate attacks on the heavily populated city of Idlib in Northern Syria, and are accused of violating international humanitarian law on several accounts.
Russia has been mediating a new deal to end the recent fighting in Daraa under which opposition groups who reject the deal will have to leave the region.
More than 100 people have been killed by Syrian regime airstrikes in northwestern Syria since June, as increased violence in the country resulted in the largest displacement recorded since March 2020.
At least six people were killed and as many others wounded by Syrian regime shelling in Sarajah village southeast of Idlib.
Violence has been rising in recent weeks in Idlib, the last-rebel enclave between the regime and its allied forces and insurgents on the edge of a territory that is home to nearly 4 million people, despite a truce brokered in March 2020.
At least eight people, including seven children, killed as regime troops and allied militants attack villages of Iblin, Meshun and Belyun in south of Idlib province, according to White Helmets.
Artillery attack on a hospital in Al Atarib town kills six civilians and wounds 15 others, according to White Helmets.
More than 20 air strikes targeted two mountains and three villages in the Jabal al Zawiya region and two other villages in the countryside of the Hama province, a war monitor and a civil defence group said.
Seven of those killed in regime and Russian strikes in Sarmeen town of Idlib province were all members of one family, Syrian Observatory for Human Rights says.
Renewed violence tightened the noose around Syria's last major rebel-held bastion and deepened an already dire humanitarian crisis.
Residents of villages and towns in southern parts of Idlib province have been fleeing while regime forces have been pushing into the northwestern province of Idlib toward a rebel-held town, Maaret al Numan.
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