Five-times a runner up at Melbourne Park, Andy Murray had surgery on the hip a year ago and has been unable to recover his best form.
Caroline Wozniacki who was diagnosed with rheumatoid arthritis, an autoimmune disease which attacks the joints, before the US Open says she is proud of how she has been so positive through it all.
Novak Djokovic races to a fourth Wimbledon title and 13th career Grand Slam crown after defeating a battling but exhausted Kevin Anderson 6-2, 6-2, 7-6 (7/3).
South Africa's Kevin Anderson became the first South African to reach the Wimbledon final in 97 years after triumphing over John Isner in the tournament's second longest match.
On 20-match winning streak at Wimbledon, Williams will face German world number 10 Angelique Kerber on Saturday in a repeat of the 2016 showpiece won by Williams.
South African Kevin Anderson's hopes looked forlorn as Federer skipped through the opening two sets on Court One with his usual panache, but he turned the match on its head to cause the biggest shock yet in a tournament full of upsets.
Tennis fans are dreaming of another final between Rafael Nadal and Roger Federer as the two have stormed into the Wimbledon quarterfinals on 'manic Monday', when all 16 fourth-round singles matches are played.
The carnage of seeds at the world's premier grass court tennis tournament continued, with only one of the top 10 women's seeds remaining in the tournament at the fourth round.
The five-time champion Venus Williams was beaten by Dutch Kiki Bertens in the third round, being the second person from last year's finalists to lose before the fourth round.
Defending champion Roger Federer defeats Lukas Lacko while sisters Serena Williams and Venus Williams advance to the next round. Meanwhile, world number two Caroline Wozniacki suffers shock defeat against Ekaterina Makarova.
Seven-time winner Serena Williams, who missed the tournament last year, faces Bulgarian qualifier Viktoriya Tomova.
Roger Federer and Serena Williams return to the tournament but hip injury forces Swiss star Andy Murray to withdraw from the championship.
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