Syrian military positions were targeted early on Thursday after an unmanned drone entered Israeli airspace from Syria the day before.
Israeli forces attacked Syrian regime military positions near the Golan Heights border in the early hours of Thursday, causing limited damage, Syrian state media said.
The Israeli military said in a statement that it hit three targets in retaliation for an incursion on Wednesday of a Syrian drone which was shot down over northern Israel.
"The IDF (Israeli Defence Forces) holds the Syrian regime accountable for the actions carried out in its territory and warns it from further action against Israeli forces," the Israeli statement said.
TRT World's Alaattin Kilic has this report from Gaziantep
Israeli-issued black-and-white surveillance footage showing missiles hitting what appeared to be a hut, a two-storey structure and a five-storey structure amid hilly terrain.
Syrian regime media said the positions targeted on Thursday were near Hader village in Quneitra province, near the Israeli-occupied Golan Heights.
"The aircraft of the Israeli enemy fired several missiles in the direction of some army positions," media cited a Syrian military source as saying. At least some of the missiles were thwarted by Syrian air defences, they said.
Israel has grown deeply alarmed by the expanding clout of its arch enemy Iran during the seven-year war in Syria. Its air force has struck scores of targets it describes as Iranian deployments or arms transfers to Lebanon's Iran-backed Hezbollah.
Israeli Prime Minister Benjamin Netanyahu told Russia on Wednesday that Israel would not seek to topple Syrian regime leader Bashar al Assad but that Moscow, his key ally, should encourage Iranian forces to quit Syria, a senior Israeli official said.
Israel has been on high alert as Syrian regime forces advance on the opposition and rebels in the vicinity of the Golan, which Israel took from Syria in the 1967 Middle East war. Israel worries Assad could let his Iranian allies entrench near its lines or that Syrian forces may defy a 1974 Golan demilitarisation.
Earlier this week, regime media said air defence systems struck an Israeli warplane and shot down Israeli missiles targeting the T4 air base in Homs province. Israel neither confirmed nor denied carrying out that strike.
With the help of heavy Russian air power, the Syrian army has seized swathes of Daraa province from insurgents in the south in the past three weeks. The offensive is expected to turn next to rebel parts of Quneitra closer to the Golan.