"Dynamite," the first all-English language single from the seven-member boy band, notches 33.9 million US streams and 300,000 sales in its first week, according to Nielsen Music data.
K-Pop band BTS has roared to the top of the Billboard Hot 100 singles charts in the US.
It is another milestone cementing the seven-member boy band's global dominance, coming hours after BTS beat American heavyweights including Lady Gaga, Ariana Grande and Taylor Swift to score the Best Pop award at Sunday's MTV Video Music Awards.
The first BTS single sung completely in English, "Dynamite" was released August 21 and tallied 33.9 million US streams in just a week, with 300,000 units sold.
In securing the top spot, the song unseats Cardi B's raunchy hit "WAP" featuring fellow rapper Megan Thee Stallion, a not-safe-for-work bop that held number one for two consecutive weeks.
The South's President Moon Jae-in congratulated the septet, calling their latest achievement "truly amazing".
"It is a splendid feat that further raises pride in K-pop," Moon said in a statement.
The milestone is "all the more meaningful" as the song was composed to comfort those affected by Covid-19 worldwide, he added.
Formed in 2013, BTS has spearheaded the K-Pop drive into the United States over the past three years with catchy, upbeat music.
'Harvest of hard work'
BTS's achievement comes after it reached the Billboard Hot 100's fourth slot in March with its song "On."
Three of BTS' albums have hit number one on Billboard's album charts, but this is their first Hot 100 top single.
Billboard's all-genre Hot 100 blends US streaming, radio airplay and digital sales data to rank the top hits.
Fans around the world were overjoyed by the news, with one saying in a tweet: "I'm so proud of our boys! They are finally reaping the harvest of their hard work and perseverance!"
BTS is the first all-South Korean group -- comprised of J-Hope, Jimin, Jin, Jungkook, RM, Suga and V -- to reign over the chart.
South Korean soloist PSY reached number two for seven weeks in the fall of 2012 with his viral dance juggernaut "Gangnam Style."
The first Asian artist to top the chart was Japanese-born crooner Kyu Sakamoto, whose "Sukiyaki" held the ranking for three weeks in June 1963.
K-pop -- along with K-drama soap operas -- has been one of South Korea's most successful cultural exports.
A key component of the "Korean Wave" that has swept Asia and beyond over the last two decades, the K-pop industry is estimated to be worth about $5 billion .