Researchers say they traced the DNA of a jawbone found in a cave on the Tibetan Plateau to the Denisovans, a defunct cousin of modern humans.
The fossilised remains of an early human cousin found in the mountains of Tibet proves mankind adapted to live at high altitude far earlier than previously thought, scientists said on Wednesday.
A jawbone dating from at least 160,000 years ago of a Denisovan – a now-extinct branch of humanity – is the first of its kind discovered outside of southern Siberia, and experts believe it holds the key to understanding how some modern-day humans have evolved to tolerate low-oxygen conditions.
Contemporaries of the Neanderthals – and like them, possibly wiped out by anatomically modern man, Homo sapiens – the Denisovans first came to light a decade ago.
Their existence was determined through a piece of finger bone and two molars unearthed at the Denisova Cave in southern Siberia's Altai Mountains and dated to some 80,000 years ago.
Latest protein analysis
But the new remains – discovered in passing by a local monk nearly thirty years ago – has led researchers to conclude that Denisovans were far more numerous, and far older, than previously thought.
"To have beings, even if a little archaic, living at 3,300 metres (11,000 feet) on the Tibetan plateau 160,000 years ago ... That's something that no one could have imagined until today," said Jean-Jacques Hublin, director of the Max Planck Institute's Department of Human Evolution.
The bone, found in the Baishiya Karst Cave in Xiahe, China, was donated by the monk to a local museum, before scientists set about analysing its composition. It was so old no DNA could be extracted.
But Hublin and his team used the latest protein analysis to date one of its teeth and to link it genetically to Denisovan specimens found in Siberia.
"From my point of view it's confirmation of a working hypothesis I've had for a while: Nearly all Chinese and east Asian (hominim) fossils between 350,000-50,000 years ago are probably Denisovan," said Hublin, lead author of the study published in the scientific journal Nature.
A recent research paper suggested that humans only reached the Tibetan plateau – a vast area of mountainous terrain north of the Himalayas – around 40,000 years ago.
"Here we have something that's four times older," said Hublin.
"It's absolutely extraordinary."
WOW new #Denisovan fossil identified- and it's from Tibet, exactly where one might have predicted based on high-altitude related DNA that's come down in living population.— Becky Wragg Sykes (@LeMoustier) May 1, 2019
Cave is +1000m higher than any known #Neanderthal site.https://t.co/CwitqrzSKR
The jawbone discovery also solves a riddle that has troubled anthropologists for years.
In 2015 researchers found that ethnic Tibetans and Han Chinese living at altitude had buried in their genetic code an unusual variant of a gene, EPAS1, which regulates haemoglobin, the molecule that hauls oxygen around the blood.
At high altitude, common variants of the gene overproduce haemoglobin and red blood cells, causing the blood to become thick and sludgy – a cause of hypertension, low birthweight and infant mortality.
Denisovans of Tibet
But the variant found in Tibetans increases production by much less, thus averting hypoxia problems experienced by many people who relocate to places above 4,000 metres in altitude.
The mutation is nearly identical to that found in the DNA of Denisovans discovered in Siberia – at an altitude of less than 700 metres.
"That was something that no one really understood, because the Denisovans weren't known to live at altitude, so they didn't really need that gene to survive," said Hublin.
"Now we know why. It's not the DNA from Denisovans from [Siberia], it's the DNA from the Denisovans of Tibet."